A Simple and Cost-effective Weight Drop Model to Induce Contusive Spinal Cord Injury: Functional and Histological Outcomes

Background: Animal spinal cord injury (SCI) models have provided a better perception of the mechanisms related to traumatic SCI and evaluation effectiveness experimental therapeutic interventions. Objectives: The aim this study is develop cost-effective modified Allen's device induce contusive injury. Methods: Adult male Wistar rats were subjected using customized weight drop model through 10-g weights delivered from 25-mm height onto an exposed cord. Locomotor sensory function during 28 days assessed. Moreover, histopathological changes assessed at one week post SCI. Results: All showed hind limb paralysis up 48 h neuropathic pain after Histological similar previous reports for contusion observed. Conclusions: According our findings, little variability was observed in BBB score individual Our simple inexpensive alternative method highly sophisticated commonly used